Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic Silencer Element
نویسندگان
چکیده
منابع مشابه
Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element.
Induction of the prodynorphin gene has been implicated in medium and long-term adaptation during memory acquisition and pain. By 5' deletion mapping and site-directed mutagenesis of the human prodynorphin promoter, we demonstrate that both basal transcription and protein kinase A (PKA)-induced transcription in NB69 and SK-N-MC human neuroblastoma cells are regulated by the GAGTCAAGG sequence ce...
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Protein kinase A-dependent derepression of the human prodynorphin gene is regulated by the differential occupancy of the Dyn downstream regulatory element (DRE) site. Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for cyclic AMP-dependent derepression of the prodynorph...
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Differential regulation of the human nidogen gene promoter region by a novel cell-type-specific silencer element.
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.12.6921